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International Conference and Exhibition on Spectroscopy and Analytical Techniques, will be organized around the theme “Advancements and Scope of Spectroscopy in Modern Chemistry”
Global Spectroscopy 2019 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Global Spectroscopy 2019
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Mass spectrometry (MS) is feasibly regarded as the most important analytical spectroscopic tool of modern times. MS is a technique used to measure the mass of ions that are electrically charged species, derived from atoms or molecules. The fundamental atomic and molecular processes can be understood well by this technique and helps to control processes in chemical and biological industries, in diagnosing diseases, discovery of new drugs, protecting the environment and explore mysteries of nature. This particular track would evolve the significances of analysis of biomolecules and certain ionization techniques. This would also focus on the data analysis through softwares engaged in MS.
MS technique has a blended feature in industrial and academic fields for routine and research purposes. Mass spectrometry has become an indispensable technique with a myriad of different applications in biology, chemistry, and physics and in clinical science and even in space exploration observing air quality manning space mission and then to examine the composition of planetary atmospheres. Due to its accuracy in speed and stupendous sensitivity, mass spectrometry has also been regarded as a paramount in many phases of drug discovery. The technique finds its applications in testing water quality or potential food contamination. Therefore, MS is becoming a very prominent figure in the wings of clinical and other research endeavors such as biomedical, petro products, space research, astrochemistry and geological ground.
MS on the basis of proteomics has become an epitome in the cellular and molecular life sciences which has been enabled by the 'soft ionization' techniques of electrospray and matrix-assisted laser desorption-ionization that allows the ionization and vaporization of thermally labile biomolecules. The instrumentation directed for proteomics research have led to innovative instrumentation designs and biochemical strategies in the large-scale identification and quantification of proteins, as well as in the characterization of their complexes and post-translational modifications. These comprehensive proceedings can decipher the pathophysiology of development in diseases at a molecular level and to monitor the individual response of lifestyle intervention through pharmacology. This technique evolves indispensable implications in several areas of research such as structural proteomics, metabolomics and lipids, post-translational modifications
The LC-MS technology is a protocol replicating the use of HPLC where the components in a mixture are first separated individually followed by the procedure of ionization and then separating the ions on the basis of their mass/charge ratio by feeding those into an electron multiplier tube detector which eventually identifies and quantifies each ion. The ion is the potent source in MS analysis aiding efficiency in generation of ions for analysis. LC-MS has now became a routine technique for providing a simple and robust interface applying to a wide range of biological molecules by using of tandem MS and stabling isotope that allows highly sensitive and accurate assays. The major significance of this technology projects sensitivity, specificity and precision analysis done at molecular level. Some of these applications may be biochemical screening for genetic disorders and preluding the ideas of combinational chemistry and agro-chemistry.
The use of LCMS has become a paramount in two dimensional hyphenated technology to be useful in a wide assortment of analytical and bioanalytical techniques of nucleic acids, amino acids, peptides, proteins, carbohydrates, lipids, and etcetera and in categorizing the field of genomics, proteomics, metabolomics, lipidomics. Current trends are may be gripped of mass analyzers, ionization protocols, fast LC–MS, LC–MALDI-MS, ion mobility spectrometry used in LC–MS, quantitation issues specific to MS and emerging mass spectrometric approaches which are complementary base in LC–MS are also discussed to focus on the recent innovations in LC–MS especially from the last decade and then to enlist mass spectrometers offered currently by main manufacturers for LC–MS and MALDI-MS configurations together with the technical specifications. The forthcoming supplements in LC-MS could be emphasized on Bioanalysis, Aspects in Clinical Chemistry, Qualitative and Quantitative Analysis of Compounds
It is noticed that LC/MS system during the past 2 years has been used to quantify natural small molecules biologically.Numerous developments have been made in LCMS analysis such as phospholipids and drugs with respect to pharmacokinetics and pharmacodynamics studies interfering with the metabolism of sphingolipids. Simultaneous measurements of drugs with the levels of natural metabolites are designed to modify. The processes incorporated inLC-MS method development for the pharmacological studies includes three anti-cancer drugs (i.e., methoxyamine, fludarabine, and 6-benzylthioinosine). Some others being specific are tetra-enzyme cocktail utilizing for release of DNA adducts All these methods are applied to study the drug effect and drug mechanism through other integrated prospects like therapeutics and detection & determination of impurities
Liquid chromatography-mass spectrometry (LC-MS) after a prolong development has led to the introduction of some major interfacing techniques in the field of analytical toxicology and forensics Chemistry. Some of these LC-MS interfaces are legible in handling fragile species. This review is intended to present LC-MS on the applications of Forensics Chemistry and Toxicology by coupling with the techniques supplementing the evaluation of doping agents, drugs, forensic analysis, toxicity of compounds .Liquid chromatography-mass spectrometry (LC-MS) to forensic or clinical toxicology, or analytical methods are fostering technical improvements and to a decrease in the price of instruments. Most recent applications in forensic or clinical toxicology are proposed for typical applications in human toxicology for the determination of morphine metabolites with the perspectives concerning technical improvements in ionisation interfaces/sources or mass spectrometers, as well as in sample preparation and liquid chromatography techniques like Doping and Screening.
The cruelest track of ecological problems is mutagenic pollution in the environment, and thereby the determination of mutagenic compounds in environmental samples is a crucial part. Mutagens found are polycyclic aromatic compounds, heterocyclic aromatic amine compounds, azo dyes, aldehydes and pesticides. Other advanced aspects for the current analysis in LC/MS are urinary metabolites of mutagens and DNA modification. The analysis made on the residues of pesticides in food has increasingly become an important task where the screening and controlling of the quality has to be very strict in order to safeguard the consumers’ health. One of the potent goals of food quality assurance is testing food for the residues and contaminants. Among chemical hazards the contaminants found in food with pesticides has been characterized as a source of many serious diseases. Consumption of food containing pesticide residues may cause cancer, malformations, and damage to the endocrine, nervous, and immune system. Liquid chromatography-mass spectrometry methods (LC-MS) are widely recognized as an ideal, highly specific, and extremely sensitive technique for testing these contaminated food products. This track would encounter the analysis and subsidiaries supplementing an enormous breakthrough in eradicating the loss of bad health by the following- analysis of natural substances, authenticity in food technology, detection of contaminants and prosperity of benign components.
LC-MS systems usually comprise of devices for the introduction of samples that require an interface for connecting the devices where an ion source would ionize samples. Electrostatic lens used for the implication of the generated ions, mass analyzer unit which separates the ions based on their mass-charge ratio and a detector unit for detecting the separated ions. LC–MS is also has a room in proteomics where components of a complex blend must be detected and identified. This approach to proteomics generally involves protease digestion and denaturation followed by LC–MS techniques with peptide mass fingerprinting or LC–MS/MS (tandem MS) to derive sequence of individual peptides. LC–MS/MS is the paramount for proteomic analysis of complex samples where peptide masses may overlap even with a high-resolution mass spectrometer. This particular session would emphasize on Electrospray Ionization (ESI), Atmospheric Pressure Chemical Ionization (APCI), Quantitative Analysis and Hyphenation
This hyphenated technique LC-MS plays a stupendous role in the environmental field for the determination of micro-pollutants. High performance liquid chromatography coupled to tandem mass spectrometry has implied that many environmental contaminants which are highly polar or nonvolatile or have a high molecular weight need to be analyzed or identified. In this track an overview is focused on the developments of liquid chromatography mass spectrometry applied to the analysis of the main classes of micro-pollutants in aqueous and solid environmental samples and other supplements in LC-MS system. In addition to these, certain amendments are also carried forward to pharmacological activity taking into consideration of consumption deriving from their use in human and veterinary medicine. Some of these developments may impact through the following- advancements in clinical research, enhanced protocols in principles of LC-MS, informatics tools
Nanoscale liquid chromatography coupled to tandem mass spectrometry has become an indispensable tool in the field of proteomics now-a-days. The advantages are grabbed with the sensitivity of nanotechnology over conventional LC-MS that allow the analysis of various peptide mixtures in limited situations. This approach gives a strong cation-exchange, sample enrichment, reversed-phase chromatography and nanospray ion trap mass spectroscopy with data dependent tandem mass spectrometry spectra acquisition. Nanocolumn liquid chromatography and largely synonymous capillary liquid chromatography (capillary LC) are the most recent results of this process where miniaturization of column dimensions and sorbent particle size play crucial role along with the advances in mass spectrometry that has really brought a breakthrough. Configuration of Nano LC-electrospray ionization mass spectrometry (LC-ESI-MS) has become a essential tool in bioanalytical chemistry that basically indulges in proteomics. This particular session includes the brief account on pharmaceutical and biomedical research, Nano-proteomic analysis and Nano-proteomic analysis.
Secondary Ion Mass Spectrometry (SIMS) is a mature surface analysis technique with a broad range of applications in Materials Science. In this article the SIMS process is described, the fundamental SIMS equations are derived, and the main terminology is explained. The issue of quantification is addressed. The various modes of SIMS analysis including static SIMS, imaging SIMS, depth profiling SIMS and three-dimensional (3D) SIMS are discussed as are specialized analysis strategies such as the imaging of shallow and cross-sections and reverse side analysis.