Spectroscopy and Analytical Techniques

Biography

Mohamed Abdel-Rehim is a Professor in analytical and bioanalytical chemistry with more than 25-year experience (R&D) in analytical and bioanalytical chemistry, having strong background and theoretical knowledge of separation sciences and state-of-the-art instrumentation related to chromatographic separation and mass spectrometry techniques. Dr. Abdel-Rehim received his Ph.D. from the Department of Analytical Pharmaceutical Chemistry at Uppsala University. 1996-2011 he worked as Senior Scientist at Research &Development at AstraZeneca in Sodertalje, Sweden. In 2003, he was appointed as a Professor in analytical chemistry at Karlstad University, Karlstad, Sweden. In 2007, he was appointed as a Visitor Professor at the National Research Centre of Egypt (NRC). In 2011 he was appointed as a Professor in the Analytical Chemistry at Stockholm University. The main focus of his research is inventing of highly automated and integrated sample preparation techniques for the isolation of drugs and metabolites from complex matrices. Screening and determination of drugs, metabolites and biomarkers in biological samples. He has published over 200 publications (scientific papers, proceedings, patent, etc.).

Research Interest

The main focus of my research is invent of the highly automated and integrated instrumentation for the isolation of drugs and metabolites from complex matrices and the subsequent separation, identification and determination of these analytes. • Analysis of small and large molecules in biological fluids. • Screening and detection of biomarkers in CNS and Oncology diseases. • Quantification of drugs and metabolites in blood, plasma, urine and saliva. • Development of sample-preparation methods for bioanalysis including liquid-liquid extraction (LLE), solid phase extraction (SPE), protein precipitation, solid-phase microextraction (SPME) and microextraction by packed sorbent (MEPS) for plasma and urine samples. • Development of new methods and validation of the methodology for determination of drugs and metabolites in biological fluids using GC-MS and LC-MS/MS. • Improvement of the separation and detection limits for gas chromatography –mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS-MS) by using interactive gases as carrier gas (GC) or as nebulizer gas in electrospray ionization with MS. I have published over 200 publications (peer-reviewed papers, proceedings, book and encyclopedia chapters, AstraZeneca internal research reports, patent, etc). I have supervised more than 18 M.Sc and Ph.D degrees. I have presented my research results in different international conferences as oral and poster presentations. Also, I have been as session chairman in different international conferences.